英國科學家發現心房顫動并發癥生物標記物
發布時間：2013-12-17 09:28:36 來源：微測生物 點擊量：次
患有心房顫動癥的患者通常也會伴隨一些并發癥。最近英國的科學家研究出一種生物標記物能夠幫助鑒定患者是否會患有這種并發癥。來自英國伯明翰大學的研究人員調查了1279名心房顫動的患者后發現，如果患者體內一種BTP蛋白含量越高，其患心房顫動并發癥的可能越大，嚴重時甚至會導致死亡。BTP目前已經被用來作為一些腎臟疾病和炎癥的生物標記物。
詳細英文報道：
Patients with atrial fibrillation, a common cardiac arrhythmia, are often at a heightened risk for stroke and other health problems. But researchers in the U.K. and elsewhere believe they have identified a biomarker that can help screen for folks who face a greater likelihood of complications.
Scientists at the University of Birmingham in the U.K. and colleagues pursued the research, and the journal CHEST details their work. MedPage Today highlights the findings.
The research team studied 1,279 elderly atrial fibrillation patients treated with an oral drug to prevent blood clots, according to the story. With this class of patients, they found that high levels of beta-trace protein, or BTP, could be linked to larger risks of everything from "embolic events" to cardiac problems, bleeding and death. Additionally, they surmised that BTP levels added to other risk scores helped improve the process of identifying potential health complications in atrial fibrillation patients.
Interestingly, BTP has already been in play as a possible biomarker, but for factors such as kidney damage, inflammation and hypertension, the MedPage Today article pointed out.
These are promising early results, but the data include plenty of limitations. As the article notes, the researchers themselves acknowledge that their work only looked at patients on a regular oral anticlotting drug at a certain point in time. Further research must include a broader class of patients to determine if BTP can be a reliable biomarker to help identify atrial fibrillation patients with an added risk of other health problems.
As hard as it might be to spot atrial fibrillation patients at risk of more problems, doctors struggle to definitively identify the condition in the first place and apply targeted treatments. The med tech industry, meanwhile, is trying to fill the gap. Topera, a 2013 Fierce 15 winner, recently won U.S. and EU approval for a 3-D device and mapping tool designed to better detect cardiac rhythm problems such as atrial fibrillation in order to enable more targeted and accurate treatment. In late August, St. Jude Medical ($STJ) snatched up Endosense, which makes a cutting-edge irrigated ablation catheter designed to treat atrial fibrillation, and rival companies are developing or promoting electrophysiology treatments and other devices for the condition.
